Ethanolamine → HCID 21071615, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 2-(2-(7-fluoro-1H-indol-3-yl)ethyl)isoindole-1,3-dione in 25 mL of THF. Add ethanolamine (63.4 g, 62.65 mL, 1038 mmol, 100 eq.) with vigorous stirring and heat to 70° C. After 1.5 hours, cool to room temperature. After 18 hours, pour reaction mixture into of water (250 mL) containing of 5N NaOH (3 mL) and extract with Et2O (2×200 mL). Combine the organic layers and wash with 0.1N NaOH. Collect the organic layer, dry over MgSO4, filter, and remove the solvent in vacuo to give the title compound as a yellow oil.

Provenance & Evidence