Hydrochloric Acid → 2-oxo-2-(5-phenoxy-1H-indol-3-yl)acetamide

Participants

Reaction Steps

Combine 2-oxo-(5-phenoxy-1H-indol-3-yl)acetyl chloride (2.15 g, 7.18 mmol), and ammonium hydroxide (28–30%, 32 ml, 680 mmol) and stir for 2 hours. Pour the reaction mixture into 10% (aq.) HCl, extract with dichloromethane, combine the organic layers and dry over Na2SO4, evaporate solvent in vacuo to give 1.94 g (96%) of title compound: 1H NMR (300 MHz, CDCl3) 4.87 (s, 2H), 7.51–7.91 (m, 7H), 8.13–8.24 (m, 3H).

Provenance & Evidence