HCID 21071457, compound → HCID 21071583, compound

Participants

Reaction Steps

Combine 3-(2-nitroethyl)-5-methoxycarbonyl-1H-indole (280 mg, 1.1 mmol), PtO2 (200 mg) and 15 mL MeOH and hydrogenate at atmospheric pressure overnight. Filter reaction mixture through a pad of celite, concentrate the filtrate, and chromatograph on silica gel eluting with 5% MeOH in CHCl3 mixed with conc. NH4OH to give the title compound as an oil: ISMS 219 (M+1); 1H NMR (CDCl3) 9.01 (s, 1H), 8.36 (s, 1H), 7.88–7.85 (m, 1H), 7.32–7.24 (m, 1H), 7.05 (s, 1H), 3.91 (s, 3H), 3.05–3.01 (m, 2H), 2.93–2.89 (m, 2H), 1.22 (bs, 2H).

Provenance & Evidence