HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methylthio-5-trifluoromethyl-1H-indole → 5-(trifluoromethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methylthio-5-trifluoromethyl-1H-indole | HCID 21071433 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(trifluoromethyl)-1H-indole | HCID 2763075 | — |
Reaction Steps
Combine moist Raney nickel (330 g), 2-methylthio-5-trifluoromethyl-1H-indole (33.8 g, 146.2 mmol) and absolute ethanol (850 ml) and stir. After 1.5 hours, filter the mixture through celite and wash the celite with ethanol (500 ml). Evaporate the filtrate to dryness, add toluene (20 ml) and evaporate and dry to give 5-trifluoromethylindole: mp=55–60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157488B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-de4e169c35db4b5d968949cc7017f7e7 |
| Source note | uspto-grants-2007_01 |