反应详情

Combine 3-propoxybenzaldehyde (14.05 g, 0.0856 mole) and 5-methoxytryptamine (13.64 g, 0.0717 mole) in 390 mL absolute EtOH. Add molecular sieves (19.2 g) and heat the suspension to reflux. After 4 hours, cool to room temperature and add NaBH4 (37.32 g, 0.2146 mole) in 3 portions. Stir the mixture for 1 hour at room temperature, filter, evaporate the filtrate to a mass of about 100 g, add water and dichloromethane. After separation, wash the aqueous phase with dichloromethane, combine the organic layers, dry over MgSO4, filter, evaporate the solvent in vacuo to afford the title compound.

1. additionAdd molecular sieves (19.2 g)
2. temperatureheat the suspension
3. temperatureto reflux
4. filtrationfilter
5. customevaporate the filtrate to a mass of about 100 g
6. additionadd water and dichloromethane
7. customAfter separation
8. washwash the aqueous phase with dichloromethane
9. dry with materialdry over MgSO4
10. filtrationfilter
11. customevaporate the solvent in vacuo