HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 3,3,3-Trifluoroprop-1-yl toluene-4-sulphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 3,3,3-Trifluoro-1-propanol | HCID 137512 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3,3,3-Trifluoroprop-1-yl toluene-4-sulphonate | HCID 12635340 | — |
Reaction Steps
Add 3,3,3-trifluoropropan-1-ol (61.8 ml) and pyridine (224 ml). Cool to between 0° C. and 10° C. and add portion-wise p-toluenesulfonylchloride (147 g). Allow to warm to ambient temperature and stir overnight. Add HCl 0.5N (1.6 L), extract with ethyl acetate, combine the organic layers, dry over MgSO4, filter, and evaporate to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157488B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-8b683b9ed17041afb862a8ed35a00419 |
| Source note | uspto-grants-2007_01 |