HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Phenoxy-1-methyl-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Nitro-p-cresol | HCID 16271 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 4,6-Difluoro-5-methoxy-1-methyl-1H-indole | HCID 21071555 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Phenoxy-1-methyl-2-nitrobenzene | HCID 21071562 | — |
Reaction Steps
Combine phenyl boronic acid (7.32 g, 60 mmol), 4-methyl-3-nitrophenol (4.5 g, 30 mmol), and Cu(oAC)2—H2O (6 g, 30 mmol) in 30 mL CH2Cl2 and treat with 6 g 4 A molecular sieves powder. Add Et3N (15.18 g, 150 mmol) dropwise, and stir the reaction at ambient temperature for 8 days. Dilute with 100 mL CH2Cl2 and filter through celite and concentrate to dryness. Purification by chromatography using 2% EtOAc in hexanes gave the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157488B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-f2a550f7062e42a5ad6d89d5e249d614 |
| Source note | uspto-grants-2007_01 |