HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron trifluoride etherate → 3-(trifluoroMethyl)-5-isopropyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Ethyl trifluoroacetate | HCID 9794 | — |
| Reactant | 3-Methylbut-1-yne | HCID 69019 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(trifluoroMethyl)-5-isopropyl-1H-pyrazole | HCID 23006214 | — |
Reaction Steps
Following protocol H, 3-methylbutyne was treated with n-BuLi, CF3CO2Et and BF3-OEt2 in THF. Reaction with hydrazine in benzene under similar reaction conditions yielded title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-01d0ceb134bc40ac8828bf4528464efe |
| Source note | uspto-grants-2007_01 |