HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-Chloro-1-[4-(4-chloro-phenyl)-2-methyl-(R)-piperazin-1-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (3R)-1-(4-chlorophenyl)-3-methylpiperazine | HCID 21071026 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-1-[4-(4-chloro-phenyl)-2-methyl-(R)-piperazin-1-yl]-ethanone | HCID 58778030 | — |
Reaction Steps
Protocol S was followed using 1-(4-Chloro-phenyl)-3-(R)-methyl-piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography afforded the title compound
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-f3caf3e91dec435c9ebbb19cb61afd71 |
| Source note | uspto-grants-2007_01 |