HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → 2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Bromo-3-phenyl-1H-pyrazol-5-amine | HCID 594319 | — |
| Edukt | 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine | HCID 4053957 | — |
| Lösungsmittel | Ethyl acetate hexane | HCID 21226206 | — |
| Produkt | 2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone | HCID 21071044 | — |
Reaktionsschritte
Protocol T was followed using 4-Bromo-5-phenyl-1H-pyrazol-3-ylamine, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 7.7–7.8 (m, 2H), 7.24–7.3 (m, 3H), 6.8–6.92 (m, 2H), 6.74–6.78 (m, 2H), 4.9 (s, 2H), 4.2 (s, 2H), 3.6–3.7 (m, 4H), 2.86–3.04 (m, 4H). 13C NMR (400 MHz, CDCl3): 164, 146, 145, 128, 127, 118, 114.8, 60.2, 50.4, 50, 48.8, 46, 42, 22.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07157464B2 |
| Quelldatensatz | uspto-grants-2007_01 |
| ORD ID | ord-a53a4b20b88e4ef1baf6c635697c6bc2 |
| Quellennotiz | uspto-grants-2007_01 |