Dimethylformamide → 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone

Participants

Reaction Steps

Protocol T was followed using 4-Chloro-5-phenyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 7.82–7.84 (m, 2H), 7.4–7.48 (m, 3H), 6.9–7.04 (m, 2H), 6.88–6.94 (m, 2H), 5.22 (s, 1H), 3.76–3.88(m, 2H), 3.6–3.68 (m, 2H), 3.1–3.22 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.2, 130.4, 128, 126, 118.2, 116.4, 52.2, 50, 44, 41.8.

Provenance & Evidence