HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-bromo-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-3-methyl-5-(trifluoromethyl)pyrazole | HCID 2736430 | — |
| Reactant | 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine | HCID 4053957 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-bromo-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone | HCID 21070996 | — |
Reaction Steps
Protocol T was followed using 4-Bromo-5-methyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 6.96–7.1 (m, 2H), 6.84–6.89 (m, 2H), 5.2(s, 2H), 3.6.2–3.8 (m, 4H), 3.0–3.16 (m, 4H), 2.32 (s, 3H). 13C NMR (400 MHz, CDCl3): 162, 146.4, 142.2, 118.5, 116.2, 52, 50.4, 46.2, 42.2, 15.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-5bd94cfb7c0d49a4a1d3ed3bf3e3cdc6 |
| Source note | uspto-grants-2007_01 |