Dimethylformamide → 1-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-(3-thiophen-2-yl-pyrazol-1-yl)-ethanone

Participants

Reaction Steps

Protocol T was followed using 3-(2-thienyl)pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3); 7.48–7.52 (d, 1H), 7.24–7.28 (dd, 1H), 7.14–7.2 (dd, 1H), 6.98–7.2 (m, 1H), 6.88–6.96 (m, 2H), 6.78–6.84 (m, 2H), 6.46–6.52 (d, 1H), 5.0 (s, 2H), 3.64–3.8 (m, 4H), 2.94–3.1 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.4, 158, 152.2, 144, 134, 132, 126, 124, 123.8, 118, 116, 115.8, 102.2, 54, 51.2, 50.8, 45.8, 42.2.

Provenance & Evidence