Dimethylformamide → 2-(4-Chloro-3-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)piperazin-1-yl]-ethanone

Participants

Reaction Steps

Protocol T was followed using 4-Chloro-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as colorless oil. 1H NMR (400 MHz, CDCl3): 7.64–7.68 (d, 1H), 6.98–7.4 (m, 2H), 6.86–6.92 (m, 2H), 6.98–7.2 (m, 1H), 5.4 (s, 2H), 3.78–3.84 (m, 2H), 3.68–3.92 (m, 2H), 3–3.1 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.4, 158, 152.2, 144, 132, 118.2, 116, 54, 50.2, 50.0, 46.0, 42.2.

Provenance & Evidence