Dimethylformamide → HCID 21071037, compound

Participants

Reaction Steps

Protocol T was followed using 3-(4-Fluoro-phenyl)-5-methylsulfanyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 7.7–7.76 (m, 2H), 6.96–7.1 (m, 4H), 6.88–6.92 (m, 2H), 6.64 (s, 1H), 5.3 (s, 2H), 3.7–3.84 (m, 4H), 3.04–3.2 (m, 4H), 2.5 (s, 3H). 13C NMR (400 MHz, CDCl3): 164.8, 152, 140, 127.4, 119, 118.4, 118.2, 116.2, 116, 108, 52.8, 52, 51.8, 45.4, 42.2, 20.

Provenance & Evidence