Dimethylformamide → HCID 21071068, compound

Participants

Reaction Steps

Protocol T was followed using 4-Chloro-3-(4-Fluoro-phenyl)-5-methylsulfanyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 7.82–7.88 (m, 2H), 7.06–7.12 (m, 2H), 6.96–7.1 (m, 2H), 6.88–6.92 (m, 2H), 5.2 (s, 2H), 3.68–3.84 (m, 4H), 3.06–3.18 (m, 4H), 2.4 (s, 3H). 13C NMR (400 MHz, CDCl3): 164.8, 158, 147, 135, 127.4, 127, 119, 112.4, 112.2, 110, 108.8, 52.8, 52, 51.8, 45.4, 42.2, 18.6.

Provenance & Evidence