Dimethylformamide → HCID 58778004, compound

Participants

Reaction Steps

Protocol T was followed using 3-Trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as colorless oil. 1H NMR (400 MHz, CDCl3); 8.15 (s, 1H), 6.98–7.04 (m, 2H), 6.86–6.92 (m, 2H), 5.1 (s, 2H), 4.28–4.38 (q, 2H), 3.78–3.84 (m, 2H), 3.62–3.74 (m, 2H), 3.04–3.2 (m, 4H), 1.3–1.4 (t, 3H). 13C NMR (400 MHz, CDCl3): 163.4, 160.5, 159.2, 156.2, 147, 137.2, 119, 118.8, 116, 115.8, 61, 54, 50.8, 50.0, 45.0, 42.2, 14.2.

Provenance & Evidence