Dimethylformamide → 2-(3-Chloro-indazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone

Participants

Reaction Steps

Protocol T was followed using 3-Chloro-1H-indazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3) 7.64–7.70 (m, 1H), 7.38–7.48 (m, 2H), 7.18–7.26 (m, 2H), 6.94–7.0 (m, 2H), 6.82–6.88 (dd, 2H), 5.2 (s, 2H), 3.72–3.82 (m, 4H), 3.02–3.08 (m, 4H). 13C NMR (400 MHz, CDCl3): 165, 158.2, 142.8, 134.8, 128.8, 128.4, 122, 121.6, 118.8, 118.6, 115.4, 115.2, 110.6, 110.0, 51.8, 50.6, 50.2, 45.2, 42.

Provenance & Evidence