Dimethylformamide → 1-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

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Protocol T was followed using 1H-Pyrazole-3,5-dicarboxylic acid diethyl ester, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 7.38 (s, 1H), 6.94–7.0 (m, 2H), 6.82–7.90 (dd, 2H), 5.54 (s, 2H), 4.36–4.42 (q, 2H), 4.26–4.32 (q, 2H), 3.60–3.80 (m, 4H), 3.02–3.20 (m, 4H), 1.22–1.42 (m, 6H). 13C NMR (400 MHz, CDCl3): 164.2, 162.2, 158.2, 157.4, 156.2, 148.5, 144.4, 134.2, 118.4, 116.2, 115.8, 114.2, 62, 61.8, 54.2, 50.6, 50.2, 45.2, 42.2, 14.6, 14.2.

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