HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-(5-Amino-3-furan-2-yl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(furan-2-yl)-1H-pyrazol-5-amine | HCID 523183 | — |
| Reactant | 1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine | HCID 1848511 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(5-Amino-3-furan-2-yl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone | HCID 21071116 | — |
Reaction Steps
Protocol T was followed using 3-Furan-2-yl-2H-pyrazol-5-ylamine, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using 100% ethyl acetate afforded the title compound as a white solid. 1H NMR (400 MHz, CD6CO); 7.48–7.52 (m, 1H), 6.98–7.06 (m, 2H), 6.52–6.56 (m, 2H), 6.44–6.48 (m, 2H), 5.74 (s, 1H), 4.98 (s, 2H), 3.68–3.88 (m, 4H), 3.12–3.24 (m, 4H). MS (ES) M+H) expected=369.4, found 370.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-0a89f622aeb74cd893c1cb83e33bc77d |
| Source note | uspto-grants-2007_01 |