Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-(3-Amino-4-chloro-5-methyl-pyrazol-1-yl)-1-[4-(4-chlorophenyl)-piperazin-1-yl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-chloro-5-methyl-1H-pyrazol-3-amine | HCID 1380716 | — |
| 반응물 | 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine | HCID 4053957 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 2-(3-Amino-4-chloro-5-methyl-pyrazol-1-yl)-1-[4-(4-chlorophenyl)-piperazin-1-yl]-ethanone | HCID 21071047 | — |
반응 단계
Protocol T was followed using 4-Chloro-5-methyl-1H-pyrazol-3-ylamine, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3): 7.18–7.22 (d, 1H), 6.78–6.84 (d, 2H), 4.8 (s, 2H), 4.4 (s, 2H), 3.72–3.82 (m, 4H), 3.08–3.18 (m, 4H), 2.14 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07157464B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-36651c73b0dd46af8fe3af760fcef550 |
| 출처 메모 | uspto-grants-2007_01 |