HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 58778043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate | HCID 683559 | — |
| Reactant | 1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine | HCID 1848511 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 58778043 | HCID 58778043 | — |
Reaction Steps
Protocol T was followed using 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3): 6.94–7.1 (m, 2H), 6.84–6.88 (m, 2H), 5.52 (s, 2H), 4.78 (s, 2H), 4.24–4.32 (q, 2H), 3.74–3.82 (m, 4H), 3.0–3.1 (m, 4H), 2.3 (s, 3H), 1.31–1.38 (t, 3H). MS (ES) M+H expected 389.43, found 390.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-ad957a5f3fd4425eaf7b4121c56e65d2 |
| Source note | uspto-grants-2007_01 |