HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 21071041, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-bromo-5-methyl-1H-pyrazol-3-amine | HCID 1241299 | — |
| Reactant | 1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine | HCID 1848511 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21071041 | HCID 21071041 | — |
Reaction Steps
Protocol T was followed using 4-Bromo-5-methyl-1H-pyrazol-3-ylamine, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography ethyl acetate afforded the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3): 6.94–7.02 (m, 2H), 6.82–6.88 (t, 2H), 4.84 (s, 2H), 4.1 (s, 2H), 3.72–3.78 (m, 4H), 3.04–3.08 (m, 4H), 2.16 (s, 3H). MS (ES) M+H expected 317.37, found 318.1. MS (ES) M+H expected 396.27, found 396.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157464B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-d98fcbba86674467ab3abaaab1ef37e7 |
| Source note | uspto-grants-2007_01 |