Dimethylformamide → 2-(5-tert-Butyl-3-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine	HCID 1848511	—
Reactant	HCID 178440980	HCID 178440980	—
Solvent	Ethyl acetate hexane	HCID 21226206	—
Product	2-(5-tert-Butyl-3-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone	HCID 21071123	—

Reaction Steps

Protocol T was followed using 5-tert-Butyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3) 6.94–7.08 (t, 2H), 6.82–6.88 (dd, 2H), 6.32 (s, 1H), 5.14 (s, 2H), 3.62–3.80 (m, 4H), 3.05–3.18 (m, 4H), 1.35 (s, 9H). MS (ES) M+H expected 412.43, found 413.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07157464B2
Source dataset	uspto-grants-2007_01
ORD ID	ord-0415f97e89214cbe887f23ff335af120
Source note	uspto-grants-2007_01