Dimethylformamide → 2-(2-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-oxo-ethyl)-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester

Participants

Reaction Steps

Protocol T was followed using 5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester, K2CO3, 2-Chloro-1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compound. 1H NMR (400 MHz, CDCl3): 7.34–7.38 (m, 1H), 7.24–7.26 (m, 1H), 7.12 (s, 1H), 7.04–7.08 (dd, 1H), 6.96–7.2 (m, 2H), 6.88–6.94 (m, 2H), 4.32–4.42 (q, 2H), 3.52–3.58 (m, 4H), 3.05–3.35 (m, 4H), 1.32–1.42 (m, 3H). 13C NMR (400 MHz, CDCl3): 164.2, 128, 126.8, 126.6, 120.2, 118.4, 115.2, 62.5, 54.2, 50.5, 42.6,44, 14.6.

Provenance & Evidence