Dimethylformamide → 2-(4-Chloro-3-n-propyl-5-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-ethanone

Participants

Reaction Steps

Protocol T was followed using 4-Chloro-3-n-propyl-5-trifluoromethyl-1-H-pyrazol, K2CO3, 1-[4-(4-Chloro-3-methoxyphenyl)-piperazine-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=3/7, Rf=0.78) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3); 7.22–7.24 (d, 2H), 6.42–6.48 (m, 2H), 5.7 (s, 2H), 3.8 (s, 3H), 3.72–3.78 (m, 4H), 3.22–3.42 (m, 4H), 2.66–2.72 (t, 2H), 1.58–1.68 (m, 2H), 0.98–1.02 (t, 3H). 13C NMR (400 MHz, CDCl3): 164, 154.8, 150.5, 130, 109.8, 102.2, 56.4, 52.8, 50, 49.8, 45.2, 42.6, 26, 21.8, 14.

Provenance & Evidence