Dimethylformamide → 1-[4-(4-Chloro-3-methoxyphenyl)-piperazin-1-yl]-2-(4-chloro-5-[3-Fluoro-phenyl]-3-trifluoromethyl-pyrazol-1-yl)-ethanone

Participants

Reaction Steps

Protocol T was followed using 4-Chloro-5-[3-Fluorophenyl]-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3, Rf=0.59) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 7.64–7.68 (d, 1H), 7.56–7.62 (d, 1H), 7.36–7.42 (m, 1H), 7.22–7.24 (m, 2H), 7.08–7.12 (m, 1H), 6.42–6.52 (m, 2H), 5.2 (s, 2H), 3.9 (s, 3H), 3.62–3.82 (m, 4H), 3.12–3.22 (m, 4H).

Provenance & Evidence