Bromine → HCID 21071786, compound

Participants

Reaction Steps

To a −20° C. solution of 7-(4-methoxyphenyl)-1-benzothiophene (500 mg, 2.08 mmol) in CH2Cl2 (15 ml) was added Br2 (8.33 ml of 0.25 M stock in CH2Cl2, 2.08 mmol) over 45 minutes. The reaction was stirred for an additional 0.5 h, washed with water, dried over Na2SO4, passed through a silica plug and concentrated to give 660 mg (100%) of product as a yellow solid. Further purification was done by recrystalization from 3% EtOAc in hexanes: mp 103–104° C.; 1H NMR (300 MHz, DMSO-d6): δ 3.84 (3H, s), 7.12 (2H, d, J=8.7 Hz), 7.31 (1H, d, J=7.9 Hz), 7.54 (1H, d, J=5.6 Hz), 7.65 (2H, d, J=8.7 Hz), 7.72 (1H, d, J=7.9 Hz), 7.98 (1H, d, J=5.6 Hz).

Provenance & Evidence