反应详情

A mixture of 500 mg (2.79 mmol) of 4-carboxyphenylisothiocyanate and 5 ml of thionyl chloride was refluxed for 6 hours. The reaction mixture was concentrated at reduced pressure and the resulting tan solid was pumped at high vacuum overnight. The solid was triturated with a small amount of hexane and collected by suction filtration to yield 516 mg (93%) of product as an off-white solid.

1. temperaturewas refluxed for 6 hours
2. concentrationThe reaction mixture was concentrated at reduced pressure
3. customwas pumped at high vacuum overnight
4. customThe solid was triturated with a small amount of hexane
5. filtrationcollected by suction filtration