1-(3-Aminopropyl)-4-methylpiperazine → HCID 58779629, compound

Participants

Reaction Steps

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (1.0 g, 6 mmol) was reacted with 1-(3-aminopropyl)-4-methylpiperazine (1.06 mL) to give 0.38 g (23% yield) of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid [3-(4-methyl-piperazin-1-yl)-propyl]-amide using General Amidation Procedure 1. 1H-NMR (360 MHz, dimethylsulfoxide-d6) δ 11.8 (br s, 1H, NH), 9.52 (s, 1H, CHO), 7.52 (m, 1H, CONH), 3.2 (m, 2H, CH2), 2.8 (m, 2H, CH2), 2.5 (m, 8H, 4×CH2), 2.34 (s, 3H, CH3), 2.29 (s, 3H, CH3), 1.68 (m, 2H, CH2). MS m/z 307 [M+1].

Provenance & Evidence