Morpholine → HCID 21071894, compound

HRID 1372423Notes

Reaction equation

[CH:1]([C:3]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([OH:14])=O)[C:4]=1[CH3:18])=[O:2].[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH3:18][C:4]1[C:5]([C:9]2[CH:17]=[CH:16][CH:15]=[C:11]([C:12]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[O:14])[CH:10]=2)=[C:6]([CH3:8])[NH:7][C:3]=1[CH:1]=[O:2]

Participants

Reactant 2

HCID 8083Morpholine

HCID 21071898HCID 21071898, compound

Product 1

HCID 21071894HCID 21071894, compound

Procedure

3-(5-Formyl-2,4-dimethyl-1H-pyrrol-3-yl)-benzoic acid was reacted with morpholine using General Amidation Procedure 1 to give 3,5-dimethyl-4-[3-(morpholine-4-carbonyl)-phenyl]-1H-pyrrole-carbaldehyde. MS m/z 326 [M+1].

Sources & evidence

ORD record: ord-38bb9affcde347348b3354185ff8ded1
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157577B2

Reaction notes

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