Hydrochloric Acid → HCID 69483553, compound

Participants

Reaction Steps

A 1L round bottom flask equipped with a reflux condenser and a Teflon-coated magnetic stirring bar was charged with compound 2 (30 g, 73.8 mmol) and MeOH (1 L). 6N HCl (45 mL) was added and the slightly cloudy reaction mixture was heated to a gentle reflux with stirring for 48 hours. The reaction mixture was cooled to ambient temperature and concentrated to dryness to give a white colorless solid, which was dissolved in H2O (300 mL) and extracted with CH2Cl2 (50 mL). The aqueous phase was concentrated to give the title compound as a white colorless solid (22.7 g, 89%).

Provenance & Evidence