Ammonia → HCID 20241990, compound

HRID 1372478Notes

Reaction equation

HRID 1372478 reaction equation
[NH3:1].[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7](=[NH:11])OCC>C(O)C>[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7]([NH2:11])=[NH:1]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21071767690258-15-2

Product 1

HCID 20241990HCID 20241990, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ammonia gas was bubbled into an ice-cold suspension of the product (1.00 g, 3.21 mmol) from Step A in 20 mL of absolute ethanol for 20 min. The resultant clear solution was allowed to warm to room temperature and stirred for 48 h. The reaction mixture was then concentrated under reduced pressure, and the residue was triturated with diethyl ether. The supernatant was decanted, and the residual gummy product was dried in vacuo to afford the title compound as white foam.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customthe residue was triturated with diethyl ether
  3. customThe supernatant was decanted
  4. customthe residual gummy product was dried in vacuo

Sources & evidence

ORD record
ord-0db41156346b41e385a9917975453e08
Source dataset
uspto-grants-2007_01
Patent number
US07157490B2

Reaction notes

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