2-Amino-5-bromopyridine → N'-(5-Bromopyridin-2-yl)-N,N-dimethylformimidamide

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 5-bromo-2-aminopyridine (3.0 g, 17.3 mmol) in N,N-dimethylformamide (6 mL) was added N,N-dimethylformamide dimethyl acetal (5.37 g, 45.0 mmol). The reaction mixture was heated to 130° C. overnight. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the desired product as a brown oil. LC/MS 227.8 (M+1)

Provenance & Evidence