Sodium Hydroxide → HCID 17859292, compound

Participants

Reaction Steps

In THF (70 mL) was dissolved ethyl 4-(2-benzoxazolylamino)phenylacetate (2.08 g, 7.02 mmol), followed by the addition of 0.25N NaOH (42.0 mL, 10.5 mmol) at room temperature. After stirring for 24 hours, the reaction mixture was poured in 1N HCl (50 ml) at 0° C. The crystals thus precipitated were collected by filtration, whereby 4-(2-benzoxazolylamino)phenylacetic acid (1.85 g, 98%) was obtained as a solid.

Provenance & Evidence