Water → HCID 58778976, compound

Participants

Reaction Steps

In ethanol (50 ml), ethyl 4-(N′-(2-methylphenyl)thioureido)-3-(4-methoxybenzylthio)phenylacetate (1.63 g, 3.40 mmol) and mercuric oxide (yellow) (1.10 g, 16.4 mmol) were stirred for one hour at 70° C. Water (50 ml) was added and the mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column, whereby from hexane-ethyl acetate (3:1) eluate fractions, ethyl 2-(2-methylphenylamino)-6-benzothiazolylacetate (922 mg, 83%) was obtained as a pale yellow oil.

Provenance & Evidence