Sodium Hydroxide → HCID 58779027, compound

Participants

Reaction Steps

In THF-methanol (1:1, 20 ml) was dissolved ethyl 2-(2-methylphenylamino)-6-benzothiazolylacetate (907 mg, 2.78 mmol). To the resulting solution was added 1.0M-NaOH (8.34 ml, 8.34 mmol), followed by stirring overnight at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was acidified with 1.0N HCl. The crystals thus obtained were collected by filtration under reduced pressure, washed with water and dried at 60° C. under reduced pressure, whereby 2-(2-methylphenylamino)-6-benzothiazolylacetic acid (675 mg, 81%) was obtained as a white crystalline powder.

Provenance & Evidence