HCID 67404444, compound → HCID 67405408, compound

Participants

Reaction Steps

Methyl (E)-6-((2S,4S)-1-(tert-butoxycarbonyl)-4-fluoro-2-pyrrolidinylmethoxy)-2-hexenoate (1.90 g, 5.50 mmol) and 5% palladium/carbon (1.0 g) were suspended in methanol (80 ml). The resulting suspension was subjected to catalytic hydrogenation under normal pressure for 19 hours under stirring at room temperature. The catalyst was filtered off and the filtrate was distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column (silica gel: 3 g), whereby from ethyl acetate eluate fractions, the title compound (1.92 g, 100%) was obtained as a colorless oil.

Provenance & Evidence