Sodium Hydroxide → HCID 17859156, compound

Participants

Reaction Steps

Methyl 2-(2-chlorophenyl)amino-7-fluoro-6-benzoxazolylacetate (2.12 g, 6.33 mmol) was dissolved in THF/methanol (2:1, 90 ml). To the resulting solution was added 1N NaOH (30 ml) and the mixture was stirred at room temperature for 3.5 hours. The solvent was distilled off under reduced pressure. The residue was acidified with 1N hydrochloric acid. The crystals thus precipitated were collected by filtration, washed with water and dried under reduced pressure, whereby 2-(2-chlorophenyl)amino-7-fluoro-6-benzoxazolylacetic acid (1.83 g, 90%) was obtained as a colorless solid.

Provenance & Evidence