2-Chlorobenzoxazole → HCID 58778601, compound

Participants

Reaction Steps

In xylene (100 ml), 2-chlorobenzoxazole (326 μl, 2.86 mmol) and ethyl (3-amino-2-chloro-6-pyridyl)acetate (557 mg, 2.59 mmol) were heated under reflux for 4 hours under stirring. After the reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column, whereby from n-hexane/ethyl acetate (3:1, v/v) eluate fractions, ethyl (3-(2-benzoxazolyl)amino-2-chloro-6-pyridyl)acetate (460 mg, 53%) was obtained as a colorless gum.

Provenance & Evidence