Sodium Hydroxide → HCID 17858865, compound

Participants

Reaction Steps

In THF (8 ml) was dissolved ethyl (3-(2-benzoxazolyl)amino-2-chloro-6-pyridyl)acetate (460 mg, 1.39 mmol). To the resulting solution was added 0.5N NaOH (8.0 ml, 4.00 mmol). The resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was poured in ice-1N HCl to acidify the mixture. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-(2-benzoxazolyl)amino-2-chloro-6-pyridyl)acetic acid (332 mg, 79%) as a white solid.

Provenance & Evidence