2-Bromo-4-chlorobenzothiazole → HCID 58778599, compound

Participants

Reaction Steps

In xylene (7 ml), 2-bromo-4-chlorobenzothiazole (647 mg, 2.60 mmol), methyl 4-amino-3-chlorophenylacetate (520 mg, 2.60 mmol), and pyridinium•p-toluenesulfonate (PPTS) (200 mg, 0.80 mmol) were heated under reflux for 7 hours. After cooling, the reaction mixture was distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column, whereby from n-hexane/ethyl acetate (6:1, v/v) eluate fractions, methyl (4-(4-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate (556 mg, 58%) was obtained as a yellow amorphous substance.

Provenance & Evidence