Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → Ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate

Participants

Reaction Steps

In xylene (5 ml), 2-bromo-5-fluorobenzothiazole (548 mg, 2.36 mmol), ethyl 4-amino-5-chloro-2-fluorophenylacetate (547 mg, 2.36 mmol), and pyridinium p-toluenesulfonate (PPTS) (178 mg, 0.71 mmol) were heated under reflux for 3 hours. After cooling, the reaction mixture was distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column, whereby from n-hexane/ethyl acetate (7:1, v/v) eluate fractions, ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate (298 mg, 33%) was obtained as a pale yellow solid.

Provenance & Evidence