Hydrochloric Acid → HCID 17859325, compound

Participants

Reaction Steps

Ethyl 2-chloro-3-(1-methyl-3-indolylcarbonyl)amino-6-pyridylacetate (859 mg, 2.31 mmol) was dissolved in THF (25 ml). To the resulting solution was added 0.25N NaOH (13.9 ml, 3.47 mmol), followed by stirring at room temperature for 4 hours. Methanol-water (1:1, v/v, 10 ml) was added, and the mixture was stirred at 50° C. for 2 hours. The reaction mixture was acidified with 1N HCl (5.0 ml). The crystals thus precipitated were collected by filtration, washed with water, and dried under reduced pressure to give 2-chloro-3-(1-methyl-3-indolylcarbonyl)amino-6-pyridylacetyl acid (702 mg, 88%) as a colorless solid.

Provenance & Evidence