Hydrochloric Acid → HCID 17858904, compound

Participants

Reaction Steps

In THF (5 ml), 0.25N NaOH (4 ml, 4.82 mmol) was added to methyl (3-chloro-4-((7-fluoro-1-isoquinolinylcarbonyl)amino)phenyl)acetate (100 mg, 0.27 mmol) and the resulting mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into 1N HCl (2.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-chloro-4-((7-fluoro-1-isoquinolinylcarbonyl)amino)phenyl)acetic acid (75 mg, 78%) as a colorless solid.

Provenance & Evidence