反应详情

温度

80 °C

To ethyl benzo(d)isoxazole-3-carboxylate (2.0 g, 10.5 mmol) was added 50 ml of 70% H2SO4. The mixture was heated at 80° C. for 4 hours. The reaction mixture was poured in ice, followed by extraction with ether. The extract was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent, whereby benzo(d)isoxazole-3-carboxylic acid (980 mg, 57%) was obtained as a colorless solid.

1. additionThe reaction mixture was poured in ice
2. extractionfollowed by extraction with ether
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. distillationdistilled under reduced pressure
5. customto remove the solvent