Tetrahydrofuran → (2-(1-Methyl-2-pyrrolyl)-6-benzoxazolyl)acetic acid

Beteiligte Stoffe

Reaktionsschritte

To methyl (2-(1-methyl-2-pyrrolyl)-6-benzoxazolyl)acetate (228 mg, 0.84 mmol) were added THF (8.5 ml) and 0.25N NaOH (5.10 ml, 1.27 mmol). The resulting mixture was stirred at room temperature for 5 hours. The reaction mixture was poured in 1N HCl (10 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (2-(1-methyl-2-pyrrolyl)-6-benzoxazolyl)acetic acid (144 mg, 67%) as a pale yellow solid.

Herkunft & Nachweise