Sodium Hydroxide → (2-(1-Naphthyl)-6-benzoxazolyl)acetic acid

Participants

Reaction Steps

To methyl (2-(1-naphthyl)-6-benzoxazolyl)acetate (223 mg, 0.70 mmol) were added THF (4 ml) and 0.5N NaOH (4.2 ml, 2.10 mmol). The resulting mixture was stirred at room temperature for 2 days. The reaction mixture was acidified 15 with ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(1-naphthyl)-6-benzoxazolyl)acetic acid (194 mg, 91%) as a pale yellow solid.

Provenance & Evidence