Sodium Hydroxide → HCID 17859124, compound

Participants

Reaction Steps

To methyl (2-(1-isoquinolinyl)-6-benzoxazolyl)acetate (166 mg, 0.52 mmol) were added THF (3 ml) and 0.5N NaOH (3.0 ml, 1.50 mmol). The resulting mixture was stirred at room temperature for 12 hours. The reaction mixture was poured in ice-1N HCl to acidify therewith. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(1-isoquinolinyl)-6-benzoxazolyl)acetic acid (138 mg, 87%) as a pale brown solid.

Provenance & Evidence