反应详情

Methyl (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetate (1.73 g, 5.50 mmol) was dissolved in THF/methanol (2:1, 30 ml). To the resulting solution was added 1N NaOH (20 ml) and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetic acid (1.60 g, 97%) was obtained as a colorless crystalline powder.

1. distillationThe reaction mixture was distilled under reduced pressure
2. customto remove the solvent
3. customThe crystals thus precipitated
4. filtrationwere collected by filtration under reduced pressure
5. washwashed with water
6. customdried under reduced pressure